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Calculate study contributions

contributions_calculation.Rd

Calculates the raw and relative information an contribution of studies to MAIC.

Usage

contributions_calculation(data)

Arguments

data

Data frame in the format of ARDSMAICR::data_genes

Value

A tibble

Details

Input columns for data_genes should be (this is the standard output of the MAIC algorithm):

  • gene - HGNC gene symbol - chr

  • 1...

  • uID - Study unique identifier. Column contains study specific gene score - dbl

  • n...

  • maic_score - MAIC score for gene - dbl

  • contributors - Studies contributing to MAIC score by method - chr

Definitions:

  • raw_information = sum of gene scores for each study

  • relative_information = raw_information/sum of all gene scores in MAIC

  • raw_contribution = sum of gene scores for each study which contribute to the MAIC score

  • relative_contribution = raw_contribution/sum of all gene scores in MAIC contributing to the MAIC score

Examples

if (FALSE) {
if(interactive()){
 contributions_calculation(ARDSMAICR::data_genes)
 }
}